Hair Loss from Steroids & SARMs: Top 10 Ways Bodybuilders Can Prevent It and Regrow Hair

Hair loss from steroids and even certain SARMs is a common frustration for bodybuilders chasing gains. Anabolic steroids and high-dose testosterone can fast-track male pattern baldness if you’re genetically prone – not exactly the look most lifters want to go with their new muscle. The good news is there are proven methods to stop hair loss on SARMs or steroid cycles and even regrow thinning hair. This comprehensive guide will review 10 compounds and interventions – both oral and topical – that have shown real results. We’ll blend clinical research with gym-speak and anecdotal know-how so you get a complete picture. Whether you’re worried about a receding hairline on cycle or just want the best DHT blockers for lifters, we’ve got you covered. Let’s keep your hair gains while you make muscle gains!

Why Steroids and SARMs Trigger Hair Loss

Before diving into solutions, it helps to understand why steroids and some SARMs can wreak havoc on your hair. The root cause is the same hormone behind ordinary male pattern baldness: DHT (dihydrotestosterone). DHT is a potent androgen that binds to hair follicles and gradually miniaturizes them, causing hairs to grow thinner and shorter until they stop altogether. Steroid use turbocharges this process. Taking high amounts of exogenous testosterone (or other anabolic steroids) drives up DHT levels as your body tries to balance hormone levels. More DHT = more fuel on the fire of follicle miniaturization if you’re susceptible. In practical terms, blasting testosterone or DHT-derivative steroids (like Winstrol, Masteron, etc.) can rapidly accelerate hair thinning in those predisposed.

SARMs (Selective Androgen Receptor Modulators), often touted as a “hair-safe” steroid alternative, can also cause shedding. How? Two ways: First, SARMs often lower SHBG (sex hormone binding globulin), which in turn raises free testosterone and DHT levels transiently. Many users report a burst of shedding in the first weeks of a SARM cycle for this reason. Second, despite being “selective,” some SARMs have inherent androgenic activity in the scalp. In real-world use (especially at high doses), certain SARMs bind and activate scalp androgen receptors enough to trigger hair loss, even if on paper they’re milder than testosterone. For example, YK-11, S23, and RAD-140 are notorious among lifters for causing hair thinning, whereas others like Ostarine are generally more hair-friendly.

So, if you’re genetically prone, running steroids or strong SARMs can quickly make your hairline and crown start to fade. The key to preventing that is tackling the problem on one or more fronts: reducing DHT production, blocking DHT at the follicle, and stimulating new growth. Let’s get into the top 10 compounds and methods to do exactly that.

Diagram: DHT binds to susceptible hair follicles and causes gradual follicle miniaturization – the process underlying male pattern hair loss. Many steroids raise DHT levels, accelerating this process.

1. Finasteride (Propecia) – The Classic DHT Blocker for Hair Preservation

Finasteride is the gold-standard medication for protecting your hair on or off cycle. This oral drug (1 mg daily for hair loss) works by blocking 5-alpha-reductase, the enzyme that converts testosterone to DHT. Less DHT means less attack on your hair follicles. For any bodybuilder experiencing hair loss from testosterone or other DHT-producing steroids, finasteride is often the first line of defense.

Effectiveness: Clinically, finasteride is proven to significantly slow or halt male pattern baldness in the vast majority of men. Over a 2-year period, 83% of men had no further hair loss on finasteride, versus continued balding in placebo users. In fact, about 66% even saw regrowth of hair (ranging from slight to dense regrowth) in that time. These are huge numbers – it works. Research also shows finasteride maintains its efficacy long-term. In a 10-year study, 99% of men had no worsening of hair loss while on finasteride, and 91% saw sustained improvement. Simply put, finasteride can put the brakes on your balding. Many lifters who start finasteride notice their excessive shedding diminishes after a few months and their hair thickens up over the first year.

In the real world, gym bros will tell you “finasteride saved my hairline.” It’s one of the best DHT blockers for lifters on cycle. It’s especially effective for testosterone or Dianabol cycles (anything that increases DHT). Do note: finasteride only blocks DHT. It won’t directly help if you’re on compounds that cause hair loss without DHT (e.g. DHT-derivatives or certain SARMs). But for a test-heavy cycle, it’s a lifesaver.

Delivery & Use: Finasteride comes as a pill, typically 1 mg daily (Propecia or generic finasteride). Many start at 1 mg; some users on heavy cycles even up the dose slightly (per doctor guidance) or use a 5 mg Proscar pill split into quarters. It takes a few months to kick in – hair follicles need time to recover once DHT is lowered. Expect 3–6 months before you see noticeable reduction in shedding and initial regrowth. Consistency is key: if you stop taking it, any preserved hair will slowly be lost again as DHT rises (usually within a year you’d regress back to baseline or worse).

Safety: Finasteride is generally well tolerated, but you’ve probably heard of the infamous side effects. Around 2% of men in clinical trials experienced sexual side effects (like reduced libido or erectile difficulty). That means 98% did not. Anecdotally, in bodybuilding forums some guys worry fin will “kill your gains” or lower your mood. The science doesn’t really back that up. Studies found that even wiping out almost all DHT with dutasteride (an even stronger drug) did not hinder muscle growth or strength gains in men on testosterone. Testosterone itself is what builds muscle, and finasteride actually leaves you with more free testosterone (since less is being converted to DHT). So the “fin will hurt gains” is largely bro-science – if anything, having higher T:DHT ratio might slightly aid muscle. Most users notice no difference in gym performance. Of course, if you’re one of the unlucky few who get side effects like low libido, you can discontinue use and those sides usually resolve. In summary, for most, finasteride offers a huge upside (keeping your hair) with minimal downside.

Availability: Finasteride is a prescription medication (FDA-approved for male hair loss), so you’ll need to get it from a pharmacy or telemedicine service. It’s widely available and not expensive (especially generic). Some lifters get a doctor’s prescription, others go through online clinics that specialize in hair loss meds. Cost is typically $10–30 per month generic. Given its effectiveness, it’s often the first thing anyone worried about hair loss on cycle will consider.

Pro Tip & Anecdotes: Finasteride works best for preventing further hair loss – it’s like hitting the brakes. It can also trigger some regrowth of miniaturized hairs, but don’t expect miracles on completely bald areas. Many bodybuilders start finasteride as a preventative measure when they begin their first testosterone cycle if they know they’re prone to hair loss (say, family history of baldness). It’s common to stack finasteride with other methods (like minoxidil and ketoconazole shampoo – see below) for a multi-pronged defense known as the “Big 3” among hair enthusiasts. One thing to note: finasteride specifically should not be used with nandrolone (Deca) cycles – it sounds counterintuitive, but blocking 5-AR with Deca can actually worsen hair loss. This is because Deca converts via 5-AR to a weaker androgen (DHN); if you prevent that, more potent nandrolone is free to damage hair. So, use finasteride for testosterone or other 5-AR convertibles, but skip it for Deca. For most other situations, it’s a reliable hair-saver. Many lifters report that finasteride significantly slowed their hairline recession, letting them run moderate test cycles without going bald – as long as they started it early enough.

2. Dutasteride – The Nuclear Option for DHT Suppression

If finasteride is good, dutasteride is arguably even better at blocking DHT – though with some trade-offs. Dutasteride (brand name Avodart) is an oral drug originally for enlarged prostate, used off-label for hair loss. It inhibits not one but both forms of the 5-alpha-reductase enzyme, cutting DHT production by 90% or more (finasteride is ~70% blockade). Essentially, dutasteride is the nuclear option for eliminating DHT.

Effectiveness: Dutasteride can work where finasteride plateaus. Clinical studies show dutasteride 0.5 mg daily often yields greater hair regrowth than finasteride 1 mg. In a controlled trial, dutasteride significantly increased hair counts versus finasteride, and was judged more effective at improving scalp coverage. A meta-analysis of 30 studies confirmed dutasteride is more efficacious than finasteride for androgenetic alopecia. One study found dutasteride 0.5 mg led to visibly more hair after 24 weeks compared to finasteride. Many dermatologists consider dutasteride the strongest medical hair loss treatment available (it’s approved for hair loss in some countries like Japan and South Korea). For a bodybuilder on a heavy cycle, dutasteride’s extra DHT suppression can mean the difference between shedding and maintaining. Guys who didn’t get enough benefit from finasteride sometimes switch to dutasteride and notice further reduction in shedding and even new growth filling in.

That said, more potency can mean diminishing returns if DHT is already low enough on finasteride. Finasteride already knocks DHT down substantially; dutasteride takes it almost to zero. For many, finasteride is sufficient, but if you’re still losing hair on fin (perhaps due to very high test doses or high personal sensitivity), dutasteride could be worth it. Anecdotally, some lifters use dutasteride during particularly hair-dangerous cycles (e.g. high-dose testosterone or stacking multiple androgens) for extra protection, then go back to finasteride on cruise/off-cycle.

Delivery & Use: Dutasteride is taken as a capsule (typically 0.5 mg daily or even 2–3x a week in some protocols, since it has a long half-life). It’s actually not officially approved for hair loss in the US, but doctors do prescribe it off-label. On the grey market, some people obtain it too, but stick to legit sources if possible. Because dutasteride is so potent and stays in your system a long time, even once or twice a week dosing can maintain low DHT levels. If you start dutasteride, treat it similarly to finasteride in terms of time – give it a few months to see results. Some hair transplant doctors use dutasteride for patients who are more advanced in hair loss or didn’t respond enough to finasteride.

Safety: The side effect profile of dutasteride is similar to finasteride – possible sexual side effects, etc. In studies, rates of issues like decreased libido or erectile dysfunction were slightly higher with dutasteride, but still in the single digits percentage-wise. Many users tolerate it just fine. Because it is a stronger systemic hormone modifier, you should be cautious. One plus: research from a large review suggests dutasteride’s overall safety is on par with finasteride for most men. In practice, some men who got side effects on finasteride report no sides on dutasteride – possibly due to differences in how it suppresses DHT more uniformly (this is very individual). If you experience sides on dutasteride, discontinuing it will let DHT return, but note that dutasteride stays in the body for weeks, so side effects may take longer to fully resolve compared to finasteride.

Availability: Dutasteride is prescription (for prostate, but can be prescribed for hair). It’s a bit less commonly prescribed for hair loss, so you might need to find a doctor or clinic comfortable with it. Alternatively, some hair loss specialty pharmacies compound topical dutasteride (and some experimental folks buy raw dutasteride powder to make homemade topical solutions, though evidence for topical efficacy is limited). Generally, oral dutasteride 0.5 mg capsules are the standard. Cost can be higher than finasteride, but still reasonable in generic form.

Anecdotes: For bodybuilders, dutasteride is like the “big gun” for hair. If you’re the guy who is extremely hair-sensitive (you so much as look at a bottle of test and your hair sheds), dutasteride might be your best friend. Plenty of users on hair loss forums have shown impressive results with dutasteride – including regrowth in areas that were thinning badly. One notable point: because dutasteride so thoroughly blocks DHT, some users report slight differences in how they feel (DHT has roles in things like mood, libido, etc). Some complain of feeling a bit more “flat” or less aggressive in the gym. Others notice no change or even feel better not worrying about their hair. It’s individual. From a gains perspective, like finasteride, dutasteride does not impede muscle gains significantly, as testosterone and other anabolics do the heavy lifting for muscle growth. If keeping your hair means everything and finasteride isn’t cutting it, dutasteride is the next step up.

3. Minoxidil (Topical or Oral) – The Hair Follicle Stimulator

Moving beyond blocking DHT, we come to minoxidil, a compound that doesn’t fight hormones at all – instead it directly stimulates hair growth. Minoxidil (brand Rogaine among others) is a topical solution or foam applied to the scalp (and now also used orally in low doses) that can reinvigorate shrinking follicles and promote thicker, longer hairs. It’s like fertilizer for your hair follicles.

Effectiveness: Minoxidil is one of the only FDA-approved hair growth stimulants, and it’s a staple for regrowing hair. It doesn’t “cure” the underlying DHT issue, but it pushes hairs into a growth phase and increases blood flow and growth factors around the follicle. In clinical studies, about 65% of men using minoxidil 5% for a year show some level of hair regrowth. In a large one-year study of nearly 1,000 men on 5% minoxidil, 84% of participants rated the treatment as at least moderately effective (about 15.9% “very effective” regrowth, 47.8% “effective”, 20.6% “moderately effective”). Only ~16% saw no improvement. That means the vast majority got benefits – ranging from a bit of thickening to substantial new growth. Minoxidil tends to work best on thinning areas (like a balding crown or diffuse thinning). It can help fill in a patchy beard or thinning eyebrows too (many use it off-label for that). While minoxidil alone won’t completely counteract aggressive DHT from steroids, it will help any surviving follicles produce better hair. Think of it as helping you regrow hair you’ve recently lost or miniaturized, especially when combined with something that’s blocking the ongoing damage (like finasteride).

For lifters, minoxidil is especially useful if you’ve already experienced some hair loss and want to regain ground. Example: You ran a cycle that shed a bunch of hair – now you’re off and on finasteride, but those lost hairs aren’t coming back on their own. Adding minoxidil can often regrow a decent amount of that hair, or at least make the remaining hairs thicker. It’s not instant – typically you see results around 4–6 months in, with peak results by 12 months. Many guys see the first signs of new baby hairs after 3 months, and noticeable density by month 6 onward.

Delivery & Use: Traditionally, minoxidil is applied topically twice a day as a liquid solution or foam (5% concentration for men is standard). This is the over-the-counter Rogaine or generic minoxidil you’ll find in any pharmacy. You part your hair and apply the solution to the thinning areas, massage in, and let it dry. Some lifters incorporate this into their morning and evening routine – it only takes a minute. A common complaint is the liquid solution can leave a greasy residue or irritate the scalp; the foam is less messy and quick-drying. Both are similarly effective. Compliance is crucial: you need to apply it daily (missing occasionally won’t ruin results, but consistency yields best regrowth).

In recent years, oral minoxidil at low doses (usually 2.5mg to 5mg once daily) has emerged as an alternative. Oral minoxidil is actually a blood pressure pill, but at low dose it can spur hair growth systemically. Many dermatologists now prescribe oral minoxidil off-label for hair loss in patients who can’t tolerate or don’t respond to topical. It’s convenient (just a pill a day, no mess), and some evidence suggests oral may give even more robust hair growth than topical for certain people. However, oral has a bit higher chance of side effects (like body hair growth, slightly lower blood pressure, rapid heart rate in some, or ankle swelling). Still, lots of anecdotal success stories exist for oral minoxidil as a “set it and forget it” approach.

For a bodybuilder already popping pills and doing injections, adding a topical step might seem like a hassle – but many do it religiously for the sake of their hair. Consider minoxidil as a must if you’re looking to regrow lost hair. If you’re only concerned with keeping what you have (and you’re on top of DHT blockers), minoxidil is optional but can thicken things up. One strategy some lifters use: stay on finasteride during cycle to prevent loss, then if any thinning occurred, hit minoxidil post-cycle to help bring those hairs back.

Safety: Minoxidil’s main side effects are relatively minor for most. Topically, it can cause scalp irritation or itchiness (sometimes from the propylene glycol in the solution). Some men get increased shedding in the first 1-2 months – this is usually a sign it’s working, as hairs are cycling into a new growth phase (don’t panic, it stops). Systemically, very little minoxidil is absorbed from topical use, so systemic side effects are rare. Oral minoxidil can cause things like dizziness (from lower blood pressure), faster heart rate, or edema (swelling). A funny side effect is unwanted hair in other places – e.g. more beard growth, body hair, or random long hairs on arms, etc., due to systemic circulation. Usually it’s mild. Also, minoxidil can cause hair to grow a bit everywhere – so some guys notice their body hair gets thicker, which as a bodybuilder you might actually not want. Keep an eye on blood pressure if you go oral, and always start low (many start at 2.5mg or even 1.25mg to assess tolerance).

One safety note: Minoxidil is often avoided by those with heart issues without doctor supervision, since it was originally a hypertension med. But low doses are typically safe for healthy individuals. Always a good idea to run it by a doctor if you have any concerns.

Availability: Topical minoxidil is OTC – you can buy it easily (Rogaine, Kirkland brand, etc.). Oral minoxidil needs a prescription (compounded tablets typically, since the standard pill is a high dose 10mg for blood pressure). Cost of topical is maybe $10-20 a month. Oral can vary but generally quite cheap as a medication.

Anecdotes: Bodybuilders who use minoxidil often share impressive before-and-after photos: thin, wispy hair turned into a noticeably thicker mop over a year of use. It’s not magic – if you were slick bald, it won’t resurrect you – but if you have thinning areas, it can significantly improve them. One common scenario: a guy runs a hard cycle, sheds hair, freaks out, then starts minoxidil (with finasteride) and within 6-12 months he’s recovered much of what was lost. The combination of finasteride + minoxidil is synergistic – one stops the cause (DHT) and the other encourages regrowth. In fact, a study showed that microneedling plus minoxidil (more on microneedling later) yielded far more new hairs than minoxidil alone. So combining treatments yields the best results. The main downside you’ll hear is: “Ugh, I have to apply this forever?” Yes, you need to keep using minoxidil to maintain the growth. Stopping will likely make the new hairs shed again in a few months, essentially returning to baseline. So it’s a commitment. Many lifters are fine with that – a small daily routine to keep their hair, in exchange for running the gear they want. All in all, minoxidil is a proven workhorse for hair regrowth and definitely worth including in your hair-saving stack.

4. Ketoconazole Shampoo (Nizoral) – The Easy Anti-Androgen Adjunct

What if we told you one of the tools to fight steroid-induced hair loss is… an anti-dandruff shampoo? Yes, ketoconazole shampoo (Nizoral is the common brand) is a medicated shampoo that has secondary benefits for hair loss. Ketoconazole is primarily an antifungal used for dandruff, but research and lots of user feedback suggest that using it a couple of times a week can improve scalp health and modestly help with androgenic hair loss. It’s thought to have a mild anti-androgen effect locally on the scalp and an anti-inflammatory action that can benefit follicles.

Effectiveness: Ketoconazole shampoo is not a miracle hair growth agent, but it has shown “real results” in studies, enough that it’s often recommended as a supplementary treatment. A classic 1998 study found that men using 2% ketoconazole shampoo 2–4 times per week saw an increase in hair density over 6–15 months, while men using a placebo shampoo continued to lose hair. In fact, by 15 months, the ketoconazole group had significantly fuller hair, whereas the control group thinned out. Another part of that study compared ketoconazole shampoo to 2% minoxidil: after 6 months, ketoconazole shampoo users had a 7% increase in hair shaft diameter – essentially identical to the results in the 2% minoxidil group. That’s pretty striking, considering minoxidil is an established treatment. It suggests ketoconazole has a tangible positive effect on hair follicle thickness. Other studies and reviews have reinforced that ketoconazole (especially 2% strength) can increase the proportion of hairs in the anagen (growth) phase and improve overall hair follicle size.

Now, ketoconazole shampoo alone likely won’t save your hair if you’re blasting high-dose tren and predisposed to baldness – its effect is mild relative to the heavy hitters like finasteride. But as part of a stack of defenses, it’s extremely easy to use and has virtually no downside. Many bodybuilders include Nizoral shampoo 2-3 times a week in their routine, calling it “cheap insurance.” It might help block some DHT locally or reduce scalp inflammation from all the androgens. Numerous anecdotal reports say it helps reduce shedding and keeps the scalp healthier (some notice less oily scalp as well, since androgens increase sebum which contributes to dandruff/itching).

Delivery & Use: It’s just a shampoo! You use Nizoral 1-3 times a week in place of your normal shampoo. The key is to leave it on your scalp for a few minutes (3-5 minutes) before rinsing, to let it do its work. Most folks will wet hair, lather Nizoral in, then maybe wash the rest of their body or shave, then rinse the shampoo off after a bit. The active ingredient ketoconazole will bind to the scalp skin and some will penetrate. You can use a regular gentle shampoo on the other days. There are two common strengths: 1% (OTC in many countries) and 2% (often prescription in the US, OTC in some places). The studies were on 2%, but 1% likely has some effect too – just perhaps slightly weaker. Even using 1% Nizoral twice weekly has been associated with improvements in hair thickness in reports.

Safety: Ketoconazole shampoo is very safe when used topically. It’s been around for decades for dandruff. The main side effect could be a bit of dryness or irritation if you use it too often. It can also lighten color-treated hair over time if you dye your hair (minor issue). It’s not significantly absorbed, so you don’t have to worry about systemic side effects. Ketoconazole the pill can have systemic effects (even anti-androgenic/hormonal side effects), but the shampoo keeps it local. In the context of steroid cycles, one benefit is ketoconazole might help with any dandruff or seborrheic dermatitis that often flares on cycle (many find their skin gets oilier, scalp gets flaky – Nizoral knocks that out and in doing so possibly helps hair).

Availability: 1% Nizoral shampoo is usually over-the-counter (for example, in the US you can buy Nizoral A-D at a drugstore). The 2% might need a prescription, but you can also find generic ketoconazole 2% shampoos via online retailers or overseas pharmacies. It’s not expensive considering you’re only using it a couple times a week (a bottle can last a month or two).

Anecdotes: You won’t find people raving “Nizoral regrew my hairline!” in forums – its effects are subtle. But you will find many hair-conscious bodybuilders including it in their regimen because, as they say, “every little bit helps.” A common anecdote: guys notice less itch and inflammation on their scalp when using Nizoral regularly. That itch is sometimes associated with active hair loss. By reducing it, they suspect they’re reducing loss. One user on a forum mentioned that after adding ketoconazole shampoo to his finasteride+minoxidil routine, his shedding slowed and he felt his hair looked a bit denser after a few months. It’s not going to overcome high androgen levels alone, but it’s a great supportive therapy – sort of like a multivitamin for your scalp health. Plus, keeping your scalp clean and fungus-free is good since some studies suggest yeast on the scalp and inflammation can worsen hair loss. In sum, ketoconazole shampoo is an easy, low-cost, low-effort addition that likely gives you a modest anti-hair-loss boost on cycle. It’s one of those “can’t hurt, might help” things that enough evidence and experience suggest does help.

5. RU58841 – The Research Chemical “Secret Weapon” for Hair on Cycle

Now we venture into the experimental territory with RU58841 – a compound that has achieved almost legendary status on bodybuilding and hair-loss forums. RU58841 is a non-steroidal topical anti-androgen. In simple terms, it binds to androgen receptors in your scalp and blocks them so DHT or other androgens can’t exert their hair-killing effects there. Unlike finasteride, it doesn’t change hormone levels in your body; it just sits in the scalp and acts as a local shield. For guys on harsh androgenic steroids or SARMs, RU58841 can be a game-changer to stop hair loss on cycle.

Effectiveness: There aren’t large human clinical trials for RU58841 (it was researched in the ’90s but never brought to market), but animal studies and mountains of anecdotal evidence suggest it’s very effective at preventing androgen-induced hair loss. In a notable 1997 study, RU58841 5% solution regrew hair in bald macaque monkeys, significantly increasing hair density. Another test on human hair grafts on mice showed RU58841 increased hair growth rate and cycling compared to placebo. That’s scientific backing that RU works locally to counteract DHT. More compelling to bodybuilders are the real-world reports: for example, one SARM user on Reddit said he ran high-dose RAD-140 and S23 (very rough on hair) without losing a single hair by using RU58841 daily. He was highly prone to MPB but RU protected him, whereas he noted finasteride or dutasteride wouldn’t have been enough for those compounds. Many similar stories exist: guys on testosterone + Winstrol cycles, or SARMs, or even Tren, managing to maintain their hair by slathering RU on their scalps every day. It’s not 100% – if you blast insanely high androgens, even RU might struggle – but the consensus is RU58841 is one of the most powerful tools to prevent steroid/SARM-related hair loss.

RU essentially acts like a localized Casablanca, blocking DHT, testosterone, or whatever androgen from binding in the follicle. Finasteride reduces DHT in your blood, but if you’re on, say, Trenbolone (which isn’t DHT but still extremely androgenic to hair), finasteride won’t help because that androgen isn’t DHT. RU will help, because it doesn’t care what the androgen is – it just stops it from latching onto the follicle’s receptor. This is why community wisdom says: “finasteride for Test; RU58841 for everything else.” It covers the gap by directly guarding the follicle’s door.

Delivery & Use: RU58841 comes as a raw powder or pre-made solution sold by research chemical vendors (since it’s not an officially approved drug). Users typically apply a 5% solution (50 mg/mL) topically to the scalp once daily (some do twice, but once seems enough given its ~24h binding). You apply it to thinning-prone areas (hairline, crown) similar to minoxidil. It’s often dissolved in a quick-drying vehicle like alcohol/propylene glycol or even a minoxidil solution. It absorbs and does its work in the scalp ARs. It’s critical to get RU from a reputable source – because it’s grey-market, quality varies. Many buy the powder and mix their own solution to ensure concentration. Application is usually at night before bed. It dries in a few minutes. Since it’s alcohol-based, it can cause a bit of scalp dryness, but generally it’s well tolerated. Start using it ideally from the beginning of your cycle if you plan to use high androgens – don’t wait until a ton of hair has shed. It’s preventive primarily.

Safety: Here’s where the caution comes: RU58841 is not officially studied long-term in humans, so we rely on user experience. Most evidence suggests it stays very local due to rapid metabolism in the skin. In the animal studies, none of it was detected systemically, and no systemic side effects were noted (that was fluridil – a similar idea; but RU data on blood levels is scant). Many thousands of people have used RU by now, and reports of side effects are relatively rare. A small fraction report fatigue or low libido which they suspect if RU is absorbed, but it’s not common. Overall, users generally do not report the sexual side effects that oral finasteride can cause – which is a big reason some prefer RU. Skin irritation is possible (it’s an alcohol solution usually). One should be cautious about the source (impurities could cause issues). Because RU isn’t “legal” for human use, you’re basically experimenting on yourself, but so far there haven’t been scary reports. Still, you are on your own in that sense – there’s no doctor monitoring RU use typically.

It’s worth noting: another anti-androgen called Bicalutamide (oral) will absolutely stop hair loss but with severe systemic effects (it’s for prostate cancer). RU gives you anti-androgen action just in the scalp – a far more targeted approach.

Availability: As mentioned, RU58841 is sold as a research chemical. That means companies sell it “for laboratory use only” – but everyone knows people use it for hair. You can find it online through various vendors in the hair loss community. It is NOT sold at regular pharmacies or stores. Price can range, but a typical cost might be $30–50 for a month’s supply if you buy premixed, or cheaper if buying bulk powder. Again, quality control is an issue – stick to known suppliers that others have vetted on forums.

Anecdotes: The bodybuilding community is full of RU58841 stories. A common refrain: “RU is a miracle for keeping hair on cycle.” People have used it on everything from high test + Masteron cycles to RAD-140 to even experimental androgens. One user ‘GoodLookingAthlete’ on Reddit said he’s very MPB-prone and ran RAD140 and S23 at high doses – normally a death sentence for hair – yet lost no hair because he used RU58841 daily. He even continues using it off-cycle as maintenance. Another comment on that thread: “Order RU-58841 it will save u, [lots of people] use it”, to someone panicking about hair loss. Many concurred saying “RU is really amazing”. It almost has a cult following. Of course, not everyone loves it – some find it didn’t regrow hair (RU is more about maintaining, any regrowth is a bonus). Others are hesitant about long-term unknowns. But for serious lifters who absolutely want to run certain compounds (like DHT-derived steroids) and keep their hair, RU is often the secret weapon. It pairs well with finasteride too: fin lowers systemic DHT, RU blocks what’s left or other androgens locally – a formidable combo for hair defense.

One more anecdote: Some early adopters have been on RU for 5+ years without issues and with maintained results. There are also newer topical anti-androgens in development (like CB-03-01, coming up next), but RU58841 has been the go-to DIY solution for a while. If you go this route, do your homework on mixing and application, and you might just pull off the dream of running heavy gear while keeping a full head of hair. Just remember that the lack of formal approval means you are taking on some risk to be a bit of a biohacker here.

6. Spironolactone (Topical) – Old-School Anti-Androgen for the Scalp

Spironolactone is a medication with multiple uses – it’s a diuretic and an anti-androgen. While it’s primarily an oral drug (spironolactone pills are used to treat acne or hirsutism in women, for example), in the hair loss world topical spironolactone cream has been used for decades as a treatment to block DHT at the hair follicle level. Think of it as a less potent, more traditional alternative to RU58841 for local androgen blocking.

Effectiveness: The efficacy of topical spironolactone has been a bit controversial, but recent studies indicate it does have a positive effect on hair growth. A 2020 study on 60 patients compared 5% minoxidil, 1% spironolactone, and a combo of both: topical spironolactone 1% gel alone produced improvement in 80% of patients with androgenetic alopecia, not far behind minoxidil’s 90% improvement rate. The combo of minox+spiro gave 100% of patients improvement, suggesting an additive effect. This tells us topical spironolactone can indeed stimulate hair growth and/or reduce shedding. It likely works by blocking DHT binding in the scalp (spironolactone competes at the androgen receptor). In practical terms, many men have used spiro cream as part of their regimen and found that it helped maintain their hair, especially if finasteride wasn’t an option for them.

Spironolactone’s anti-androgen strength is lower than RU58841’s, but it’s still significant. It’s been reported to reduce sebum and greasiness on the scalp (since DHT stimulates oil) and to slow hair loss progression. Some older anecdotal evidence (pre-RU days) had users saying a 5% spironolactone cream applied to the hairline helped stop the recession from getting worse. It might not regrow a ton of hair, but can preserve what’s there by locally counteracting DHT. For steroid-using bodybuilders, topical spiro could be useful if you cannot or won’t take finasteride (some men who fear fin’s sides try spiro as a “safer” local anti-androgen). It could also be layered on top of finasteride for extra protection on cycle.

Delivery & Use: Topical spironolactone usually comes as a lotion or cream (commonly 5% concentration in a cream base, though the study above used 1% gel). There are specialty pharmacies and online vendors that compound it. You apply a small amount to the thinning areas once or twice daily. It’s often applied at night because one downside: it can have a slight odor as it dries (people describe it as a mild “cat pee” or sulfur-like smell – not super strong, but there). Newer formulations have reduced the odor issue significantly. It takes a few minutes to absorb; once dry, the smell mostly dissipates. The cream doesn’t leave much residue and you can use other topicals (like minoxidil) at other times of day.

If you DIY, some have crushed oral spironolactone pills and mixed with a cream or minoxidil liquid – but it’s better to get a properly formulated topical to ensure stability. Typical use-case: apply 5% spiro cream every night to hairline and crown. It can be used in the morning too, but if the smell or slight greasiness is an issue, stick to night.

Safety: Oral spironolactone has systemic effects (it’s actually a potassium-sparing diuretic and can cause things like lowered blood pressure, high potassium, etc., and in men it can cause libido loss or breast tenderness at high doses). Topical spironolactone, however, is not significantly absorbed systemically in most people. The studies and decades of use show minimal systemic side effects; hormone levels in blood are typically unchanged from topical use. In the study, no systemic effects were noted and histology just showed improved hair parameters. So it appears quite safe for men when used on the scalp. You won’t feminize yourself with topical spiro at normal concentrations – it just isn’t getting into your bloodstream enough. Skin irritation is rare with it, as the formulations are usually benign. As always, one should monitor if there are any unexpected effects, but the safety profile is solid.

Availability: Spironolactone cream isn’t sold in regular stores. You either get it via a compounding pharmacy (with a prescription, often a hair specialist can prescribe it) or through certain online hair loss pharmacies without a prescription (depending on the country). It’s not too expensive; a month’s supply might be $30-60 depending on source and concentration. Some brands existed in the past (e.g., Dr. Lee’s Xandrox Spiro solution, well-known in hair circles historically), but now it’s mostly custom compounded or from hair loss shops.

Anecdotes: Topical spiro was more popular before RU58841 became widely known. Many veteran hair loss forum users (especially in the 2000s) swore by the combo of finasteride + minoxidil + spiro cream as the ultimate stack. They claimed spiro really helped their hairline where finasteride sometimes fell short. There are reports of individuals maintaining a Norwood 1 (basically no recession) for many years on that trio, even with a family history of baldness. For steroid users, some who didn’t want to take oral finasteride tried just topical spiro and Nizoral shampoo and saw slower hair loss progression than they expected on cycle. It may not be powerful enough alone for a heavy cycle, but if someone is extremely cautious about systemic meds, spiro topical is an option to get some antiandrogen protection. The typical feedback: it reduces shedding and keeps hair from getting worse, but regrowth is modest. However, that aligns with the goal of prevention.

One downside often mentioned is the smell, but again that depends on formulation. Some creative users mix a drop of cologne or essential oil into the cream to mask any scent. Another tip: apply it after showering at night; by morning, you can wash your hair and no odor will remain. As far as “gym-speak” anecdotes: picture guys on forums saying “Spiro cream is like putting a DHT shield on your scalp.” It’s not as hardcore as RU, but it’s a time-tested tool. Women with female pattern hair loss use oral spiro very successfully, and some men logically extend that to topical use to avoid side effects. In summary, topical spironolactone is a solid supportive treatment – maybe not a stand-alone savior for aggressive hair loss, but in conjunction with others it can contribute to keeping your hair on your head while you’re chasing PRs in the gym.

7. Clascoterone (Breezula) – The Up-and-Coming Topical Androgen Blocker

Clascoterone (development code CB-03-01, brand name in trials Breezula) is an experimental topical androgen receptor inhibitor that could become the next big thing in hair loss treatment. It’s essentially a topical “anti-DHT” similar in concept to RU58841 or spironolactone, but developed by a pharmaceutical company (Cassiopea, now Cosmo Pharmaceuticals) and currently in Phase III trials for male pattern baldness. Bodybuilders and hair geeks are keeping a close eye on Breezula, as it promises to block DHT locally in the scalp without systemic effects, which is exactly what we want to prevent hair loss from steroids.

Effectiveness: The Phase II trial results for clascoterone were very encouraging. In a 12-month study with 400 men, a 5% clascoterone solution (applied twice daily) increased target area hair counts and hair width, while the placebo group’s hair continued to worsen. According to the company, these data confirm that clascoterone “stops the loss of hair and grows new hair”. One reported outcome was that the best responding group (7.5% twice a day) gained on the order of ~14 new hairs per cm² after 1 year. That’s comparable to, say, what finasteride might achieve for some men, and certainly better than placebo which was losing hair. In fact, Breezula’s makers believe it could be as effective as finasteride by targeting the same problem (DHT at the follicle) but from the receptor side instead of the production side. If those results hold, clascoterone could give similar hair preservation without systemic hormonal alteration.

Now, since Breezula isn’t on the market yet, we rely on trial data and a bit of off-label experimentation. Some very eager individuals have actually used Winlevi (the 1% clascoterone cream for acne that’s approved) off-label on their scalps. The concentration is lower, but a few anecdotal reports claim it reduced shedding. However, the proper hair loss formulation will be higher strength (probably 5% solution). The expectation is that clascoterone will help maintain hair and potentially regrow some, particularly in the crown and mid-scalp. Like other anti-androgens, it’s about halting the miniaturization process caused by DHT/testosterone binding.

For steroid or SARM users, Breezula could be amazing – it would be an officially tested, quality-controlled product with known dosing, to do what RU58841 does. If you’re on cycle, you could apply Breezula and block androgens in the scalp to save your hair, presumably without worrying about the wild west of research chems.

Delivery & Use: Breezula is being developed as a topical solution (likely 5%) applied twice daily. In trials, they did morning and evening applications. The solution is probably alcohol-based or similar to penetrate scalp skin. Once available, it would be a straightforward apply-and-go routine, not unlike using minoxidil or RU. Because it’s not out yet, some people obtain research samples or even raw clascoterone powder from gray market (not common yet, since it’s still patented/in trials). But for most, this is something to look forward to when it launches. The Phase III trials are underway and expected to complete by 2025, so approval could come a year or two after that if all goes well. When it does, it’ll likely be prescription.

Safety: Clascoterone’s big selling point is minimal systemic absorption. It’s designed to stay local and quickly metabolize into a much less active form (cortexolone) once it enters circulation. In trials so far, the safety profile looks very clean – essentially similar to placebo in terms of side effects. No sexual side effects have been attributed to it, and since it doesn’t lower systemic DHT, you avoid those concerns. There might be mild skin irritation for a few (as with any topical). For context, the acne version (Winlevi 1% cream) has been used by many and mainly causes some transient redness or dryness at application site, nothing major. So Breezula would likely be a safe add-on for most people, including those on steroids, since it’s not messing with your internal hormones (and thus shouldn’t affect your gains or energy or anything).

Availability: As of now (2025), clascoterone for hair is not yet commercially available. The only way to legally get clascoterone is via Winlevi (for acne) which is lower dose and a cream (not ideal for scalp, and very pricey for large area use). That hasn’t stopped a few DIYers, but in general we are waiting for Breezula. When it comes out, expect it to be a prescription product (unless OTC status is pursued, but that’s unlikely initially). The price is unknown; it could be on the higher side since it’s novel (maybe comparable to brand-name finasteride or a bit more). If it’s effective, though, many hair-conscious lifters will gladly pay for a legit topical anti-androgen to stack with finasteride or use instead of it.

Anecdotes and Expectations: While we don’t have bodybuilder-specific anecdotes for Breezula yet, we can extrapolate: Many in the community say “I can’t wait for Breezula, I’ll ditch RU once it’s here.” The idea of a vetted product is appealing. On forums like r/tressless (hair loss Reddit), some early trial participants whispered that they noticed thicker hair or that it seemed to maintain well during the 6-12 month trial. If Breezula performs as hoped, a likely scenario is: A bodybuilder on cycle could use finasteride to reduce DHT, and Breezula to block any remaining androgens at the follicle – a one-two punch akin to a “combo therapy” that could rival the potency of dutasteride or RU, but with low systemic impact.

One note: Clascoterone might also regrow some hair, but probably less than minoxidil does, since it’s more of an anti-loss agent than a growth stimulant. It’s best thought of as a powerful maintenance agent. Another plus – it may work for those who can’t take finasteride (due to sides) by offering a different mechanism to achieve a similar end result (lower DHT effect in scalp).

So, keep an eye out for Breezula. If you’re reading this in the late 2020s and it’s available, it definitely deserves a spot in a hair-conscious lifter’s regimen. Bottom line: Clascoterone is poised to be a real player in preventing hair loss from androgens, essentially giving you a prescription-grade RU58841. The future of not going bald on cycle is looking brighter!

8. Fluridil (Eucapil) – A Niche Topical Anti-Androgen with Low Systemic Impact

Fluridil (brand name Eucapil in some countries) is another topical anti-androgen worth knowing, especially for the more experimental or international readers. It’s lesser-known than RU58841 or Breezula, but it has some solid research behind it. Fluridil works by suppressing the androgen receptor in scalp follicles, much like RU or Breezula, but it has a unique trait: it’s designed to break down into inactive components upon reaching the bloodstream, meaning virtually no systemic effects. In places like the Czech Republic, Eucapil (2% fluridil solution) has been used for years as a hair loss treatment.

Effectiveness: The initial clinical data on fluridil showed promising results. In a double-blind study of 43 men with androgenetic alopecia, applying 2% fluridil daily led to an increase in the percentage of hairs in the anagen (growth) phase from 76% at baseline to 85% after 3 months, whereas the placebo group saw no change. With continued fluridil use to 9 months, the anagen hairs increased further to 87%. In other words, fluridil was able to stop ongoing hair loss and shift hairs back into growth phase. When the placebo group was crossed over to fluridil, they too went from ~76% to 85% anagen hairs over 6 months. This indicates a clear effect: it halted hair follicle miniaturization and allowed follicles to spend more time growing healthy hairs. Importantly, no fluridil or its breakdown product was detectable in the blood of users during the trial, confirming it remains localized.

Anecdotally, fluridil users often report stabilization of hair loss – they stop shedding excessively – and some moderate regrowth or thickening especially in diffuse thinning areas. It may not regrow hair as robustly as minoxidil can, but by curbing DHT’s effect it helps preserve what you have and can produce some improvement in hair caliber over time. Some hair loss forum members have used Eucapil nightly and felt it was keeping their hairloss at bay with zero side effects. For steroid-using individuals, fluridil could act as a supportive anti-androgen similar to RU58841, albeit perhaps a bit weaker in effect (some consider RU more potent). But fluridil’s big advantage is the extremely clean safety profile.

Delivery & Use: Eucapil (fluridil 2%) comes in single-use ampoules that you snap open and apply to the scalp (usually one ampoule per day). The solution is alcohol-based and dries quickly, leaving no residue. Users typically apply it at night. It’s very non-greasy and you won’t even feel it’s there after it dries. The one-use ampoules ensure the solution stays fresh (fluridil is somewhat unstable once in solution for too long, hence that packaging). If you get fluridil, you basically break the ampoule, spread the contents over the affected scalp areas, and massage it in. It’s as easy as using a vial of serum.

For those who don’t have it available locally, some order it online from European pharmacies or the manufacturer’s distributors. It’s not widely available in the U.S. except via import. The cost can be relatively high – around $60-100 for a month’s supply, depending on source – so it’s more niche indeed.

Safety: Fluridil was specifically engineered to avoid systemic effects. It’s very hydrophobic and breaks down in water, so once it hits the bloodstream (an aqueous environment) it hydrolyzes into inactive components. The study confirmed no changes in hormones, libido, sexual function, or blood chemistry in users. No irritation or sensitization was observed either, except in those using vaseline as a vehicle (which was an odd part of the patch test; fluridil itself caused no issues, vaseline did). So fluridil is about as safe as it gets – no known side effects in men. This makes it an attractive option for those who are extremely cautious. Unlike finasteride or even RU (which some worry could have unknown systemic absorption), fluridil pretty much guarantees you won’t get side effects. The trade-off might be slightly less efficacy than those stronger anti-androgens, but for a mild to moderate case, it might suffice.

Availability: Fluridil (Eucapil) is/was marketed in the Czech Republic and a few other places in Europe. You might obtain it via certain online pharmacies that ship internationally. It’s not approved by the FDA, so it’s not sold in the U.S. market via standard pharmacies. Because it’s an actual product (not just a chemical), quality is consistent – but cost is a bit high. If you’re a bodybuilder in Europe, you might have easier access. In the U.S., you’d be looking at importing it or perhaps finding if any compounding pharmacies have a formula (not common, since it’s patented/trademarked by its developers).

Anecdotes: Fluridil doesn’t get as much hype as RU58841 in bodybuilding circles, mostly due to accessibility and awareness. However, those who have used it often speak positively. For example, some users on hair forums have documented that fluridil stopped their hair loss when finasteride gave them sides – allowing them to maintain their hair without systemic drugs. A few bodybuilders tried fluridil to protect hair on moderate cycles (like low test + primo cycles) and reported it seemed to help, though they often combine it with finasteride or minoxidil, so it’s hard to isolate its effect. The consensus is that it’s effective but not a magic bullet. It’s another tool in the arsenal, especially for the risk-averse.

In a “gym-speak” context, you might not hear about fluridil as often in the locker room chat, but consider it the “stealth bomber” of hair loss treatments: it quietly does its job under the radar. If you happen to get your hands on it, it could be worth incorporating, particularly during PCT or off-cycle times to continue protecting hair without any hormonal interactions. Given its lack of systemic absorption, you could pair fluridil with any other treatment (finasteride, minox, etc.) without worry of interaction.

To sum up, fluridil/Eucapil is a safe topical anti-androgen that has shown it can stop hair loss and improve hair growth percentages, making it a viable option for those looking for every edge in their hair loss prevention strategy – even bodybuilders on the hunt for a side-effect-free hair shield.

9. Microneedling – Mechanical Stimulation to Boost Hair Regrowth

Not all interventions are chemical or pharmaceutical – microneedling the scalp is a method that has gained popularity for treating hair loss, and it can complement the above compounds. Microneedling involves using a device (like a derma-roller or derma-pen with tiny needles) to create micro punctures in the scalp skin. This controlled “wounding” triggers a healing response that releases growth factors, promotes blood circulation, and can stimulate hair follicles to enter the growth phase. It also can enhance absorption of topical treatments (making things like minoxidil or RU58841 penetrate deeper).

Effectiveness: You might be skeptical – poking your head with needles to grow hair? But there’s real evidence behind it. A notable study split men into two groups: one used minoxidil 5% alone, the other used minoxidil 5% plus weekly microneedling sessions. After 12 weeks, the combination group had far superior results – an average increase of ~12.5 hairs per square inch vs only ~1.9 hairs in the minoxidil-only group. Several patients in the microneedling group saw a >50% improvement in hair growth, whereas none in the minox-alone group did. In short, microneedling dramatically boosted the efficacy of minoxidil. Another trial in women found microneedling plus minox beat minox alone as well. A 2021 meta-analysis concluded that combining microneedling with standard treatments significantly improves hair count and thickness outcomes.

On its own, microneedling also seems to have some positive effect. The act of needling induces release of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and activates stem cells in the hair bulge area. There are case reports of people who did just microneedling (with no other treatment) and still saw some regrowth of hair, particularly when done consistently (e.g., weekly) over several months. It’s likely not enough alone for someone actively losing hair from high DHT levels (you’d need to address the cause too), but it’s a great add-on for regrowth.

For a bodybuilder, microneedling could be used as part of a comprehensive approach: e.g., you’re on finasteride or RU to stop the androgen attack, plus you microneedle and apply minoxidil to really spur new hair growth in any thinning areas. Many hair loss “stack” protocols in forums now include microneedling because of how much it can amplify results.

Delivery & Use: The tools for microneedling are cheap and accessible. A common one is a dermaroller – a small roller with dozens of tiny 0.5 to 1.5 mm needles. Another is a dermastamp or dermapen (electric device) that repeatedly pricks the skin with needles at controlled depth. For scalp hair purposes, needles of 1.0 to 1.5 mm length are often used, as they reach down near the hair bulb zone. The procedure: usually done once a week (some do twice, but you need recovery time). You roll or stamp the device on the thinning areas in multiple directions, creating little pinpoints. It’s mildly uncomfortable, akin to a prickly sensation, but not too painful (some use a numbing spray if needed). The scalp might turn red for a day or so after.

After microneedling, you often apply a topical (like minoxidil, which will absorb much more readily). Important: Many wait ~12-24 hours post-needling before applying minoxidil or RU, because applying immediately can cause too much absorption (increasing side effect risk) or irritation. There’s debate – some apply right after to maximize uptake; others caution to wait due to systemic absorption concerns. It’s best to follow what the successful study did: in the mentioned study, they applied minoxidil 24h after the once-weekly microneedling session. The rest of the week they did minox as normal. This likely balanced efficacy and safety.

Each session takes maybe 10-15 minutes of rolling. Devices should be sanitized (you’re puncturing skin, albeit micro, so clean your roller with alcohol, etc.). Replace rollers periodically as needles dull. You might get a little pinpoint bleeding – that’s okay, but you don’t need to press super hard; moderate pressure does the job.

Safety: When done correctly, microneedling is safe. The micro-wounds close within hours. Side effects can include temporary redness, scalp tenderness, or minor bleeding. Infection is a slight risk if you don’t keep things clean – always sterilize the tool and your scalp should be clean before doing it. Some users have reported shedding a bit after starting microneedling (perhaps due to follicles being shocked into a new cycle – similar to how minoxidil can cause an initial shed). This typically leads to better regrowth after. There’s also a remote risk of fibrosis or scarring if someone really overdoes it (like using too long needles too often). But with 1-1.5mm weekly, scarring is not an issue – in fact microneedling is a known therapy for reducing scars! One more thing: avoid microneedling on infected or inflamed scalp (e.g., bad acne or folliculitis on scalp) until that’s resolved, to not spread any bacteria.

Availability: You can buy a dermaroller easily online (often $10-20). A dermapen device might cost $100 or so. No prescription needed. It’s a very DIY treatment, though there are also dermatologists who perform microneedling (even with PRP, which is another combo). For our purposes, most just do it themselves at home.

Anecdotes: The hair loss community has really embraced microneedling in recent years. You’ll find lots of testimonials like, “Minox didn’t do much until I added microneedling – then my thin crown filled in dramatically.” Some share macro photos showing vellus “peach fuzz” hairs turning into thicker terminal hairs after months of combined therapy. Even some hair transplant surgeons advise patients to microneedle to improve native hair and even transplanted hair growth. For a bodybuilder noticing early thinning, adding a weekly microneedling session could significantly improve your regrowth odds along with the standard meds.

In gym terms, think of microneedling like doing farmer’s carries or deadlifts for your hair – it’s a bit tough love, but it stimulates growth and resilience. There’s also the analogy: when you work out, you create micro-tears in muscle that then repair stronger – microneedling is like a “workout” for your scalp, causing micro-injuries that lead to stronger, thicker hair growth during healing.

Some practical tips from users: Don’t microneedle right before or after a steroid injection (just to avoid compounding inflammation – though that’s more of a comfort thing). Also, if you microneedle, perhaps do it on a rest day because sweating into microneedled skin can sting a bit. But overall, it’s a simple process that once you incorporate, just becomes another part of the routine – and one that can yield visible results in a few months. Many consider it the cheapest effective hair treatment out there.

10. Saw Palmetto & Natural DHT Blockers – Mild Supportive Options

Last but not least, we should touch on the natural supplements people often talk about for hair loss: Saw palmetto, pumpkin seed oil, nettles, beta-sitosterol, etc. These are herbal or plant-based compounds purported to have DHT-blocking properties. Bodybuilders sometimes lean on these in hopes of a “natural” way to mitigate hair loss on cycle, or to add extra protection on top of meds. It’s important to set proper expectations: these are far weaker than prescription DHT blockers like finasteride. However, some studies and anecdotal evidence suggest they can have a modest effect on hair – enough to be worth considering as part of a stack, especially for those who can’t take pharma options.

Effectiveness: Saw Palmetto, a berry extract, is the most famous natural DHT blocker. It appears to inhibit 5-alpha-reductase to some degree (particularly type 1 5-AR) and possibly block DHT binding. One study compared saw palmetto (320 mg daily) to finasteride (1 mg) in men over 2 years. The results: 38% of the saw palmetto group had increased hair growth, versus 68% of the finasteride group after 24 months. Finasteride was clearly more effective, but saw palmetto did help over a third of users see improvement. That’s not negligible. The improvements with saw palmetto were mainly on the crown area and were generally milder, but it did something. Another trial using a saw palmetto topical and oral combo showed stabilization or improvement in a majority of patients, with one showing 27% increased hair count (though that was a small study). Pumpkin seed oil is another interesting one: a 2014 placebo-controlled trial found men taking 400 mg of pumpkin seed oil daily for 24 weeks saw a 40% increase in mean hair count, while the placebo group saw a slight decrease (this study is often cited by natural product enthusiasts).

For a bodybuilder, relying solely on saw palmetto to protect hair on a heavy steroid cycle is likely insufficient. However, some incorporate it as a supplementary measure. For example, taking a saw palmetto extract alongside finasteride (perhaps to try to block any residual DHT or type 1 5-AR that finasteride doesn’t cover). Or using pumpkin seed oil supplements, which contain beta-sitosterol, another 5-AR inhibitor. These naturals might offer a small additional DHT reduction or at least improve scalp health (pumpkin seed oil may also have anti-inflammatory omega fatty acids).

Another “natural” angle is caffeine shampoo or EGCG (green tea extract) topicals, which have minor evidence for supporting hair growth. Rosemary oil has even been compared to minoxidil 2% in a study, showing similar mild improvements (but far less than minox 5% would). So there’s a spectrum of gentler options.

In the big picture, I’d rate naturals as having real but modest results. If finasteride is a 9/10 in effectiveness, saw palmetto might be a 3 or 4/10 on its own. It might help anabolics users who are only on a low-dose cycle or who are in the very early thinning stage and want to delay things a bit. But it’s rarely sufficient for aggressive androgen-driven loss.

Usage: Saw palmetto is typically taken orally in a dose of 160 mg twice a day (standardized extract), or 320 mg once a day. Some hair supplements combine saw palmetto with other things (biotin, etc.). It can also be found in topical form (some shampoos or serums include it). Pumpkin seed oil can be taken as softgel capsules or as a liquid (a few teaspoons a day). These supplements are available OTC easily. Caffeine shampoos (like Alpecin) are another over-the-counter thing marketed for hair; they won’t counteract steroid-level DHT but could have a minor benefit in stimulating follicles daily (and certainly won’t harm).

Safety: These natural options are generally quite safe. Saw palmetto’s main possible side effects are stomach upset in some, or rarely, mild libido effects (because it does interact with hormones a bit). But nothing like finasteride’s potency. Pumpkin seed oil is basically a nutritional supplement and is very safe (it might even help with prostate health and cholesterol as fringe benefits). One caution: because these are mild 5-AR inhibitors, if you’re on a cycle with nandrolone (Deca), they could theoretically have a similar issue as finasteride (blocking conversion to DHN and leaving more nandrolone). But saw palmetto is so mild that it’s probably not a huge concern unless you’re megadosing it.

Availability: All these are easily available at supplement stores or online. Saw palmetto is cheap (maybe $10-20/month). Pumpkin seed oil too. Many “hair vitamins” include them along with biotin, etc., for a shotgun approach.

Anecdotes: There’s a subset of the lifting community that prefers to avoid pharmaceuticals, and they often share regimens like: “I take saw palmetto, nettle root, Pygeum, zinc, and drink green tea, and I think it’s helping my hair.” It’s hard to gauge in anecdotes because people’s hair loss can stabilize for reasons unrelated too. Some do swear that after adding saw palmetto, their shedding reduced. There are also those who tried it and continued to bald at the same pace (especially if androgens were high). One interesting anecdote: some guys on cycle include saw palmetto in their on-cycle support supplements (since it’s often included for prostate health) and believe it might slightly lessen hair shedding compared to past cycles without it.

A notable product story: PSL (Pumpkin Seed Oil) – after the 2014 study, quite a few hair loss sufferers on forums started taking it. Some posted that they saw modest regrowth or thickening after 6 months on PSL, though not as much as minoxidil would do. Still, for something that’s basically a health supplement, it was a nice bonus.

In essence, treating these naturals as “adjuncts” is the best approach. They likely won’t keep you from going bald on Tren, but they might help at the margins. And for someone coming off cycle, continuing these supplements could help maintain a healthier scalp environment. As a lifter you might already be taking some herbal support (like saw palmetto is common in prostate support blends used during cycles), so you could get a small hair benefit from that. Just don’t expect miracles. Use them to bolster your main treatments (finasteride, minoxidil, etc.), not replace them, if hair preservation is a high priority.

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Now that we’ve reviewed the top 10 compounds and methods, from FDA-approved meds to experimental chemicals and techniques, you have a comprehensive toolkit to combat hair loss from steroids or SARMs. The exact regimen you choose can be tailored to your situation – e.g. a moderate testosterone cycle might be kept safe with just finasteride and ketoconazole shampoo, whereas a harsher stack might call for finasteride + RU58841 + minoxidil + microneedling, etc. It ultimately comes down to how aggressive the hair loss triggers are, and how proactive you want to be.

To wrap up, let’s summarize these interventions in a comparison table, so you can see how they stack up in terms of effectiveness, usage, safety, availability, and how they work.

Comparison Table: Hair Loss Prevention & Regrowth Methods for Lifters

Intervention	Effectiveness (Hair Preservation/Regrowth)	Delivery Method	Safety Profile	Availability	Primary Mechanism
Finasteride (oral)	High – Prevents ~83% of hair loss; ~66% men see regrowth (mild to moderate). Best for steroid cycles that raise DHT.	Oral daily pill (1 mg).	Well-studied. Generally safe; ~2% risk of sexual side effects. No impact on muscle gains.	Rx needed (FDA-approved for hair loss). Widely available generic.	5-AR inhibitor – blocks conversion of T to DHT (lowers scalp DHT ~60%).
Dutasteride (oral)	Very High – Stronger DHT suppression than finasteride; shown to regrow more hair in trials. Great for severe cases.	Oral capsule (0.5 mg, daily or weekly).	Similar profile to finasteride. Slightly higher chance of side effects if any. Long half-life.	Rx (off-label for hair in many places). Generic Avodart available.	Dual 5-AR inhibitor – blocks Type I & II enzymes (reduces DHT ~90%).
Minoxidil (topical/oral)	Moderate-High – ~84% of men see stabilization or regrowth; ~16% “super-responders” with strong regrowth. Excellent for regrowth when combined with DHT blockers.	Topical solution/foam (1–2× daily) or low-dose oral pill (2.5–5mg).	Topical: very safe, minor skin irritation possible. Oral: low-dose can cause mild BP lowering, faster heart rate, unwanted body hair. Monitor vitals if oral.	OTC topical (5% minoxidil foam/solution). Oral by prescription (off-label).	Hair growth stimulant – increases blood flow, prolongs anagen phase (not hormone-related).
Ketoconazole Shampoo	Mild-Moderate – Adjunct treatment. Studies show increased hair density and shaft diameter with regular use. Helps reduce scalp DHT locally.	Medicated shampoo (1–2% ketoconazole) used 2–4× weekly.	Very safe topically. Possible slight dryness. No systemic absorption of concern. Also treats dandruff.	OTC in 1% form (Nizoral A-D). 2% by Rx in some countries (OTC elsewhere).	Anti-androgen & anti-inflammatory locally – may reduce scalp DHT and follicle inflammation.
RU58841 (topical)	High (anecdotally) – Many users report no hair loss on-cycle when used. Animal studies: significant hair regrowth in bald scalp models. Excellent for protecting hair from any androgen.	Topical solution (e.g. 5% – 50mg/mL) applied daily to scalp.	Limited formal data. Largely local action; users report minimal systemic sides. Need to ensure purity. Skin irritation possible from alcohol vehicle.	Research chemical (not FDA-approved). Obtained via online RC vendors; DIY mixing common.	Androgen receptor blocker – locally blocks DHT, testosterone, etc. from binding in hair follicles.
Spironolactone (topical)	Moderate – Studies: 1% gel effective in ~80% of users (mostly maintenance). Good add-on to slow hair loss, especially at hairline. Less potent than RU.	Topical cream or lotion (usually 5%) applied 1–2× daily to thinning areas.	Very safe topically (no significant absorption). Oral form has side effects, but topical avoids those. Slight odor in some formulations.	Compounded by specialty pharmacies or bought via hair loss product websites. Not mainstream OTC.	Androgen receptor antagonist – competes with DHT at follicles (local anti-androgen effect).
Clascoterone (Breezula) (topical)	Moderate-High – Phase II data: increased hair count & width over 12 mo; believed comparable to finasteride efficacy if used 2× daily. Great promise for combo therapy.	Topical solution (5% planned) applied twice daily. (Currently in trials).	Appears very safe. Minimal systemic absorption (metabolized quickly). No sexual side effects noted in trials. Mild skin irritation possible.	In development (Phase III). Not yet commercially available (as of 2025). Winlevi 1% (acne cream) available Rx – lower strength.	Androgen receptor blocker – prevents DHT/testosterone from binding in scalp (similar to RU58841 mechanism).
Fluridil (Eucapil) (topical)	Moderate – Clinical study: halted progression and increased anagen hair from 76% to 85% in 3 mo. Helps maintain hair with no systemic effects.	Topical solution 2% (ampoule) applied daily at night. Dries quickly, no residue.	Excellent safety. Non-detectable systemically. No reported systemic side effects; no effect on libido or bloodwork. Locally non-irritating for most.	Niche product (EU markets). Order via international pharmacies or manufacturer. Not sold in US retail.	Androgen receptor suppressor – binds/shuts off androgen receptors in follicles. Rapidly deactivates if absorbed (designed to be local).
Microneedling (dermarolling)	Moderate – Significantly boosts other treatments. E.g. +12 hairs/in² with minoxidil vs +2 with minox alone in 3 mo. Can trigger modest growth on its own by wound healing.	Weekly (or biweekly) scalp microneedling with 0.5–1.5mm needles (roller or pen device). Often combined with topical therapies.	Very safe if done properly. Temporary redness, slight soreness. Infection risk minimal if using sterile technique. No systemic impact.	Dermaroller or dermapen devices available OTC ($10–100). No Rx needed.	Micro-injury triggers release of growth factors & stem cell activation, improving blood supply and follicle regeneration. Enhances absorption of topicals.
Saw Palmetto & Naturals (oral & topical)	Low-Moderate – Mild DHT reduction. Saw palmetto: 38% of users saw some hair improvement (vs 68% on finasteride) over 2 years. Pumpkin seed oil showed ~30-40% increase in hair count in one trial. Best used as supportive add-on.	Oral supplements (e.g. saw palmetto 320mg daily, pumpkin seed oil 400mg). Some topical serums/shampoos with these extracts.	Generally safe. Saw palmetto can cause minor GI upset; rare sexual side effects at high doses (very uncommon). Supplements quality varies – use reputable brands.	OTC supplements and herbal products. Widely available in health stores.	Natural 5-AR inhibitors & anti-DHT effects (saw palmetto, beta-sitosterol inhibit conversion of T to DHT). Anti-inflammatory and nutrient effects for scalp (pumpkin seed oil, etc.).

Table Key: Rx = prescription; OTC = over-the-counter; 5-AR = 5-alpha-reductase; DHT = dihydrotestosterone; AR = androgen receptor.

As the table shows, each intervention has its role. For maximum protection, many bodybuilders use a stacked approach: for example, an oral DHT blocker (finasteride/dutasteride) plus a topical anti-androgen (RU58841 or eventually Breezula) plus a growth stimulant (minoxidil) and even supportive measures like nizoral shampoo or microneedling. This multi-pronged attack addresses the problem from all angles – hormonal, local receptor, and growth environment.

Final Thoughts: Preventing hair loss on steroids or SARMs is absolutely possible with diligence and the right arsenal. It often comes down to how much effort you’re willing to invest to keep your hair. Some hardcore lifters accept baldness as fate, but if you’re reading this, you likely want to keep your locks while staying swole. The good news is that science and anecdotal “bro-science” combined have given us a roadmap to do just that. From FDA-approved meds like finasteride that have proven track records, to innovative research chemicals like RU58841 that the community has battle-tested, to lifestyle tweaks like using ketoconazole shampoo, you can significantly tilt the odds in your favor.

Remember that early intervention is key – it’s easier to keep the hair you have than to regrow what’s been lost. So if you plan on running cycles and know you have the hair loss gene, start prevention before you notice major shedding. And if you’ve already noticed thinning, don’t wait – start a regimen now, as many of these treatments can not only stop further loss but even recover some ground.

It’s also worth noting that individual responses vary. You might need to experiment to find what mix of treatments your body responds best to. Always monitor for side effects and adjust if needed (for instance, if finasteride gives you issues, you might lean more on topicals and other methods). Consulting with a dermatologist who understands androgenetic alopecia can be valuable too, especially if you want medical supervision.

In summary, hair loss from steroids or SARMs isn’t a foregone conclusion. With the strategies outlined above – from finasteride to RU58841 to microneedling – many bodybuilders successfully keep a full head of hair even while running hefty cycles. It requires commitment (just like bodybuilding itself), but the reward is being jacked and having great hair, the ultimate combo! Use this guide as a reference, stay consistent with your chosen treatments, and you’ll greatly improve your chances of beating the baldness while you pursue those gains. Here’s to big muscles and good hair days ahead!

Sources:

1. De Brouwer et al. (1997). Br J Dermatol. – RU58841 increased hair growth in balding scalp grafts on mice.
2. Reddit – User report on SARMs hair loss prevention with RU58841.
3. Cotterill et al. – 2-year finasteride trial: 83% no further loss, 66% regrowth.
4. More Plates More Dates – Finasteride effects on muscle (Dutasteride trial: no muscle loss).
5. GoodLookingAthlete (Reddit) – Mechanisms of SARMs hair loss (SHBG drop -> DHT spike) and inherent SARM androgenicity.
6. Xyon Health – Steroids cause hair loss by raising DHT levels, accelerating follicle miniaturization.
7. Dhurat et al. (2013). – Microneedling + minoxidil vs minoxidil: 4x higher hair count increase with microneedling.
8. Abdel-Raouf et al. (2020). – Topical spironolactone 1% effective in 80% of AGA patients (combo with minox 100%).
9. Cosmo Pharma (2021) – Breezula phase II: clascoterone increased hair count/width; “stops hair loss and grows new hair”.
10. Sovak et al. (2002). – Fluridil 2%: Anagen hair ↑ from 76% to 85% in 3 months (placebo 0% change); no systemic absorption.
11. Pierard et al. (1998). – Ketoconazole shampoo 2%: improved hair density & diameter over 6–15 months.
12. Rossi et al. (2012). – Saw palmetto vs finasteride 24 mo: 38% vs 68% with increased hair growth.
13. Cho et al. (2014). – Pumpkin seed oil 24 weeks: ~30% increase in hair count vs placebo.
14. Hims (blog) – RU58841 summary: animal studies positive, not FDA-approved.
15. Donovan (blog) – Summary of ketoconazole’s hair benefits and 1998 study results.