RAD-140 vs RAD-150 Which is Better and What’s the difference?

RAD-140 vs RAD-150: A Veteran Lifter’s Guide to the SARM Showdown That Actually Matters

Let’s skip the sales pitch. You’re here because you’ve heard about RAD-140. Maybe you’ve even run it. And now RAD-150 is popping up like it’s the next big thing. Everyone’s asking, “Is it just RAD-140 with a new label?” or “Does the ester actually change anything?”

As someone who’s cycled both, read the studies (yeah, there are some), and coached enhanced lifters through their SARM runs — here’s the raw truth. No fluff. No hype. Just the facts and gym-floor feedback that actually matters.

What the Hell Is a SARM (and Why Do We Care)?

SARMs — Selective Androgen Receptor Modulators — are compounds designed to activate androgen receptors in muscle and bone, without nuking your liver, prostate, or skin like traditional steroids.

RAD-140 (aka Testolone) was the golden boy of SARMs — strong anabolic effect, minimal side effects, no estrogen conversion. It gained a rep as a “mild test cycle in a capsule.”

Then came RAD-150 — marketed as RAD-140’s longer-lasting brother thanks to a benzoate ester added on top. Think of it like the enanthate version of RAD-140. Same engine, longer fuel burn. That’s the theory.

But theory doesn’t mean much until you’ve pinned your macros, run a cycle, and hit PRs (or crashed and burned).

RAD-140 Breakdown: Hard-Hitting, Fast-Acting

RAD-140 hits fast. Most guys start seeing results in week one or two. Strength jumps. Pumps are wild. Appetite usually climbs. It’s like your CNS just gets dialed in and muscle protein synthesis is in beast mode.

Mechanism? It binds hard to androgen receptors in skeletal muscle. Unlike test, it doesn’t convert to estrogen or DHT. That means less bloat, fewer mood swings, and generally no gyno issues — but also no estrogenic cushioning.

TL;DR: RAD-140 Pros

Noticeable lean mass in 4–6 weeks
Strength gains are very real
No estrogen = no water bloat
Good for recomps and hard cuts

But the Downsides?

Suppression creeps in HARD by week 6
Can elevate liver enzymes (mild but real)
Aggression and libido spikes early, then crashes post-cycle
PCT is a must (don’t kid yourself)

RAD-150 Breakdown: The Long Game

RAD-150 is literally RAD-140 with a benzoate ester slapped on. That ester means it metabolizes slower. You don’t get the peak-and-trough rollercoaster. Instead, it simmers. Slow ramp up, longer effect window, fewer hormonal swings.

It’s like microdosing RAD-140… but smarter. You dose it every other day, or even 3x per week depending on the ester cleavage rate in your body (which varies per person).

Does it hit as hard? Not in the first 10 days. But give it time. The gains build quietly, and for some, persist longer even into PCT.

RAD-150 Pros

Fewer mood dips, no midday energy crash
Longer half-life = easier on hormones
Still builds solid lean mass
Dosing is less annoying (EOD)

And the Cons?

Slower to “feel” it working
Still suppresses test — don’t be fooled
Less data, less anecdotal history
Often more expensive or faked online

Head-to-Head: RAD-140 vs RAD-150 (Real Talk Table)

Factor	RAD-140	RAD-150
Half-Life	~16–20 hours	~48–72 hours
Dosing	Daily	Every other day (EOD)
Onset	3–7 days	7–10 days
Peak Strength Window	Weeks 3–6	Weeks 4–8
Suppression Level	High by week 5	Similar, more gradual
Mood Swings	Common mid-cycle	Rare
Cost/Availability	Moderate	Higher, harder to verify
Real Mass Gains	6–10 lbs in 8 weeks	6–10 lbs, more gradual
PCT Required?	100% yes	100% yes

So What Do Lifters Say?

This isn’t theory — it’s feedback from guys who’ve run these compounds.

RAD-140 reviews:

“Gains were wild, but I crashed hard in PCT.”
“Great during cut. Held onto muscle while dropping fat.”
“Suppression was brutal. My bloods tanked.”

RAD-150 reviews:

“Less edgy, no crash, strength kept climbing past week 6.”
“Didn’t feel as strong, but pictures told a different story.”
“Libido stayed more stable. Would run again over 140.”

Reddit logs, Discord SARM groups, coaching client check-ins — RAD-150 seems to offer a more even keel. RAD-140 hits harder out of the gate, but 150 might be the smarter long-game option.

PCT: Don’t Be a Dummy

Yes, both suppress you. RAD-150 doesn’t magically get around that just because it’s slow-release.

Your boys will shrink. Your LH and FSH will nosedive. Your morning wood will ghost you.

So here’s your minimum viable PCT stack:

Compound	Dose	Duration
Clomid	25–50mg/day	3–4 weeks
Nolvadex	20mg/day	4 weeks
Optional	Ashwagandha, DHEA, Tongkat	For test support

If you’re not doing bloodwork (pre/mid/post), you’re gambling with your HPTA for no good reason.

Stack Ideas That Actually Work

Don’t stack RAD-140 and RAD-150 — they’re too similar. Pick one. Then build around it.

Lean Bulk Stack (RAD-150 Focused):

RAD-150: 20mg EOD
MK-677: 20mg ED (GH/IGF boost)
GW-501516: 10mg pre-cardio (endurance + fat loss)
Length: 8–10 weeks

Cutting Stack (RAD-140 Based):

RAD-140: 15mg ED
SR9009: 30mg split doses (fat burning)
Yohimbine: 10mg AM fasted (targeted fat loss)
Length: 6–8 weeks

Support with NAC, fish oil, liver guard (TUDCA), electrolytes, and sleep dialed in.

Bloodwork Basics (No Excuses)

You want to know if you’re crashing? Test this:

Before Cycle:

Total Test
SHBG
LH/FSH
AST/ALT
HDL/LDL

Mid Cycle (Week 4):

AST/ALT
Total Test
BP, Hematocrit

Post Cycle (4 weeks after):

LH/FSH
Total Test
Liver and lipid panel

You’d tune your car. Tune your body. Simple.

Final Verdict: Which One’s Better?

It’s not black and white. But here’s the street-level summary:

RAD-140 = Fast results, hard-hitting, but rougher on mood and recovery.
RAD-150 = Slower onset, smoother ride, less suppression shock.

If you want to cut hard, hit it fast, and can handle daily dosing and suppression — RAD-140 is your beast.

If you want something a little smarter, more stable, and don’t mind waiting a bit longer for the gains to show — RAD-150 is underrated and worth it.

TL;DR for Bros Skimming on the Toilet:

RAD-140: fast gains, hits hard, harder PCT
RAD-150: smoother gains, longer acting, less mood swing
Don’t skip PCT — or your balls will pay
Bloodwork or bust
Pick based on your goal, lifestyle, and tolerance for suppression

References

PubChem RAD-140 profile
GTx Inc. SARM development pipeline
“SARMs and Liver Toxicity,” Journal of Steroid Biochem, 2020
WADA Prohibited Substances List (SARMs section)
/r/SARMs, /r/PEDs anecdotal logs
Genemedics Clinical Notes on TLB-150
PCT protocols from TRT forums and coaching logs