Superdrol Guide – Dosage – Half life Methasterone

Superdrol (methasterone) is one of the most potent oral anabolic steroids ever developed, known for delivering rapid lean muscle gains and dramatic strength increases in short cycles. While many lifters report adding 8–12 lbs of lean body mass in just 3–4 weeks, Superdrol’s hepatotoxicity, blood pressure spikes, and lipid strain make it a compound that demands serious respect and post-cycle planning.

What it is: A 17-α-alkylated DHT-derived oral steroid (brand-popularized as “Superdrol”) prized for unusually strong strength/lean-mass effects in very short runs.
Why it hits so hard: High anabolic activity relative to androgenicity in classic assays, non-aromatizing DHT base, and 17-α-methylation that makes it orally bioavailable (and hard on the liver).
The catch: It is one of the harshest orals for lipids and liver—cholestatic injury, HDL crashes, and blood-pressure spikes are common.
Half-life: Roughly 6–10 hours, which is why users often split daily dosing.
Cycle length seen in the wild: Short—2–4 weeks—because side effects escalate rapidly after week 2–3 for many.
Results people report: Rapid scale weight and big strength jumps; a portion is glycogen/water; keepable lean tissue varies.
Side effects: Liver strain (including cholestatic jaundice), severe HDL suppression/LDL rise, hypertension, “back pumps,” lethargy, appetite issues, acne, hair loss risk, testosterone suppression.
Red flags to stop immediately: Dark urine, pale stools, itchy yellowing skin/eyes, right-upper-quadrant pain, extreme fatigue, or sustained BP spikes.

What Superdrol is (and what it isn’t)

Chemical name: Methasterone (a.k.a. methyldrostanolone)
Family: Dihydrotestosterone (DHT) derivative
IUPAC descriptor (simplified): a 2-α, 17-α-dimethylated 5-α-androstane with a 3-one and 17-β-ol—in plain English: drostanolone with a 17-α-methyl group that makes it orally active and liver-toxic.

Non-aromatizing: As a DHT derivative, it does not convert to estrogen. Estrogenic sides (bloat/gyno) are low; BP can still rise from other mechanisms (mineral balance, vasoconstriction, training stress).
Androgen receptor–centric: Effects are via AR binding and downstream protein synthesis/nitrogen retention; no progestin activity in the classic sense.
Why it feels “dry” and hard: DHT backbone + lack of aromatization often yields a hard, full look (much of the quick size is glycogen + intracellular water rather than subcutaneous bloat).

History & legality (how it landed in the gym bag)

1950s–60s: Synthesized and described in the medical literature (Syntex era) but never commercialized as a prescription drug.
Mid-2000s: Entered the supplement gray market as “prohormone/designer steroid” under names like Superdrol; widely used due to potency.
2010s onward: Enforcement actions; methasterone is scheduled as an anabolic steroid in the U.S. (and controlled in many countries). Label-swapped “clones” appeared and disappeared.
Today: It’s part of the controlled substances landscape. Products sold as “research chemicals” are variable in identity and purity—a non-trivial safety risk on top of the intrinsic toxicity.

Pharmacology basics

Oral bioavailability: Conferred by 17-α-alkylation, which lets more of the drug survive first-pass metabolism—the same change drives liver toxicity (especially cholestatic patterns).
Half-life: Best estimates ~6–10 hours. Practically, many who use it split dosing (AM/PM) to smooth peaks/valleys.
A/A ratio: Classic animal assays assigned a high anabolic to androgenic ratio (often cited ~>300: <30 versus methyltestosterone). Treat these ratios as directional, not gospel for humans.
Metabolism/excretion: Hepatic metabolism; metabolites detectable in urine for a period after cessation (exact window varies by assay).
Aromatization/5-α-reduction: Already 5-α-reduced and cannot aromatize. Estrogen blockers typically don’t change much about Superdrol’s side-effect profile.

How people actually run it (observational, not advice)

Because of potency and toxicity, Superdrol is rarely run like a “normal” oral. Short runs are the rule.

Reported daily amounts: 10–20–30 mg/day, often escalated (e.g., 10 mg days 1–4, 20 mg week 1–2, 30 mg if tolerated). Some lifters stop escalating because sides outpace gains.
Splitting: With a ~8-hour midpoint half-life, split doses (e.g., 10 mg AM / 10 mg PM) are common.
Duration: 2–4 weeks is what you most often see; beyond 4 is where labs and symptoms commonly go sideways.
Stacks: Many keep it solo (or with a non-hepatotoxic base) because stacking orals compounds liver and lipid stress.

Again: We aren’t recommending use. These are observations from logs and coaching notes to help you understand why this compound carries the reputation it does.

What results look like (dosage vs. outcomes)

There’s no controlled human dosing literature like a prescription drug. The grid below is anecdotal/observational, aggregating typical outcomes from experienced lifters’ logs. Individual response varies hugely based on training age, nutrition, and whether someone is returning to prior set-points.

Daily amount	Typical run	Scale change (2–4 wks)	Strength	Look/feel
~10 mg	2–3 weeks	+2–6 lb	Modest but noticeable; bar speed ↑	Fuller muscles, minimal bloat, lower lethargy
~20 mg	3–4 weeks	+5–12 lb	Big jumps on core lifts (5–15%+ for many)	“Dry-full” look, pumps can be extreme
~30 mg	≤3 weeks	+8–15 lb (not all keepable)	Max strength pops	Sides often spike (BP, lethargy, back pumps)

Reality check: A chunk of early weight is glycogen + intracellular water. Keepable lean tissue after washout is typically smaller than the peak scale increase. Strength tends to hold better than size if training and food remain on point.

Side effects & risk profile (what shows up, when, and how it resolves)

1) Liver stress (the big one)

What happens: Superdrol is notorious for cholestatic liver injury—bilious flow is impaired, labs show elevated bilirubin and alkaline phosphatase, sometimes with less dramatic ALT/AST.
Onset: 2–6 weeks in many case reports; some users see yellowing/pruritus sooner.
Symptoms: Dark urine, pale stools, generalized itch, jaundice, RUQ discomfort, fatigue.
Resolution: After cessation, bilirubin can take weeks to months to normalize; pruritus can linger. Severe cases require medical care and can be protracted.

2) Lipids & cardiovascular

Pattern: HDL often tanks (into the teens or single digits), LDL rises, blood pressure climbs; pumps make high-rep work uncomfortable.
Onset: Within 1–2 weeks; peaks toward the end of a run.
Resolution: 2–6+ weeks post-cessation for many, longer if baseline wasn’t healthy. Fish oil, dietary fixes, and time help; medical management may be indicated if extreme.

3) “Back pumps” and cramps

What it is: Debilitating lumbar/psoas pumps during squats/deads; calf/forearm cramping.
Onset: Days to 2 weeks.
Resolution: Usually fades within days after stopping. Stretching, electrolytes, and lower volume help; taurine is a popular cramp aid (mixed evidence).

4) Lethargy, appetite, mood

What it is: Many report daytime fatigue, blunted appetite, occasional irritability.
Onset: Week 2–3 is common.
Resolution: Typically improves within 1–3 weeks post-run.

5) Androgenic effects

What it is: Acne, oily skin, accelerated hair loss in genetically susceptible users. DHT-family compounds can be unforgiving on hair.
Onset: Variable; can show within days if predisposed.
Resolution: Acne/skin normalize over weeks; hair loss can be permanent.

6) Endocrine suppression

What it is: HPG axis suppression (testosterone/FSH/LH down). Libido can swing either way during the run; often drops after.
Onset: Suppression within 1–2 weeks is routine for orals.
Resolution: Natural recovery can take 4–8+ weeks after cessation. Many pursue SERM-based PCT under medical oversight.

7) Kidney & rhabdo (less common but serious)

What it is: Rare reports of AKI or rhabdomyolysis in the context of dehydration/insane training loads plus orals.
Onset: Typically with compounding stressors.
Resolution: Medical management; prevention is hydration and sanity.

Practical health safeguards (if someone chooses to ignore the risks)

I’d rather you don’t run Superdrol at all. If someone proceeds anyway, harm-reduction best practices from experienced lifters/coaches look like:

Short, planned duration (measured in weeks, not months).
No stacking hepatotoxic orals; avoid alcohol and acetaminophen entirely during and for a while after.
Pre/during/post labs: CMP (ALT/AST/ALP/total & direct bilirubin), lipid panel, CBC, fasting glucose, blood pressure. Check mid-run—not just after.
Stop at the first red flag: Dark urine, jaundice, RUQ pain, severe pruritus, or sustained BP >140/90—see a physician immediately.
Supportive supplements (adjuncts, not shields): Many lifters use TUDCA (bile-acid support) and N-acetyl cysteine (oxidative stress), plus omega-3s for lipids. These don’t guarantee safety.
Spacing orals: Build in long off-periods; keep overall yearly oral exposure low.
Post-cycle care: Work with a clinician if you pursue SERMs or need medical management of lipids/BP. Keep training volume sensible while recovering.

Who is a bad candidate (even if “experienced”)

Any history of liver disease, cholestasis, elevated baseline bilirubin, or gallbladder issues
Uncontrolled hypertension, dyslipidemia, or a strong family history of early CVD
Dermatologic androgen sensitivity (aggressive hair loss/acne) if that outcome is unacceptable
Anyone unable or unwilling to obtain labs and seek medical help for adverse signs

Frequently asked practicals

Does Superdrol cause gyno?
It doesn’t aromatize, so classic estrogen-driven gyno is uncommon. However, shutdown + rebound or contamination in underground products can muddy the picture. Nip sensitivity isn’t a reliable diagnostic; labs are.

Why do pumps feel different—almost crippling?
Superdrol seems to exaggerate intracellular water/glycogen and vasoconstriction under load; lumbar musculature is especially sensitive during heavy compounds. Scale back volume or rotate movements if it becomes performance-limiting.

Is most of the weight “fake”?
Not fake—but a meaningful fraction is glycogen/water. Keepable lean tissue depends on total protein/calories, training density, and whether you’re pushing beyond your historical set-point.

How long until I feel normal after?

BP & pumps: often days to 2 weeks
Energy/appetite: 1–3 weeks
Lipids: 2–6+ weeks
Liver labs: weeks to months if cholestasis occurred
Hormones/libido: 4–8+ weeks (individual)

Bottom line for advanced lifters

Superdrol is popular because it works fast—not subtly. The same properties that make it effective also make it one of the least forgiving compounds you could choose:

Pro: Rapid strength and visual impact in a short window; non-aromatizing “dry-full” look.
Con: Severe lipid and liver stress, high probability of BP spikes and training-limiting pumps, and meaningful suppression after very short use.

If your priority is long-term performance and health, the risk-reward calculus rarely favors Superdrol versus smarter training/nutrition or, if one insists on AAS under medical supervision, less hepatotoxic routes with clear lab oversight.