SARMs stands for selective androgen receptor modulators. This FAQ explains the terminology, how to evaluate research, and where to find compound-specific information in the FitScience library.
What does “selective” mean in SARMs?
SARMs interact with androgen receptors and are studied for differences in their effects across tissues. Selectivity describes a research aim and pharmacological property; it does not mean that a compound affects only muscle or has no systemic effects. See the FDA overview of SARMs for the regulatory and safety context.
Which compound guide should I start with?
Start with the compound you are researching: RAD140 (Testolone), YK11, or browse the SARMs research library. Use the SARMs comparison tables to locate topics, then read the individual references before drawing conclusions.
Are SARMs FDA-approved?
The FDA describes SARMs sold in bodybuilding products as unapproved drugs whose safety and effectiveness have not been reviewed and approved. A product being available online is different from regulatory approval. The agency also reports serious adverse events associated with these products.
Does a clinical study prove a bodybuilding claim?
Not by itself. Check the participants, study design, dose, duration and measured outcome. A finding in patients with a specific disease may not apply to healthy recreational lifters. Cell experiments and animal studies are different evidence categories from controlled human trials. Changes in lean mass, strength and clinical outcomes should not be treated as interchangeable results.
How should I interpret a half-life estimate?
Look for the original pharmacokinetic source and its study population. A reported half-life describes drug concentration over time under the study conditions; it does not independently establish an effective or safe personal dosing schedule. For an example of study-specific reporting, see the RAD140 guide.
Are SARMs permitted in tested sport?
USADA identifies SARMs as prohibited anabolic agents. Athletes should check the rules that apply to their sport and competition.
Where can I find related training and nutrition research?
The exercise science hub covers training and technique. The nutrition hub connects protein, macronutrient and food-comparison resources. These topics provide context when evaluating claims about changes in performance or body composition.
